New T-FINDER Platform Provides Deep Insights Into T Cell Responses Against Novel Cancer Vaccine

Researchers at the BioMed X Institute and the Universitätsmedizin Mannheim just published the results of their collaboration around a new neoepitope vaccine in diffuse midline glioma in Science Advances.

HEIDELBERG, GERMANY / ACCESSWIRE / February 6, 2024 / BioMed X and the Universitätsmedizin Mannheim announced today the publication of two manuscripts in the field of cancer immunology in the journal Science Advances. The work is based on a collaboration between both institutions and researchers at the German Cancer Research Center (DKFZ), the University of Heidelberg, and the Helmholtz Institute for Translational Oncology (HI-TRON). The main objective of the collaboration was to understand the role of specific T cell responses in a patient with an aggressive subtype of diffuse glioma who showed sustained remission after receiving a neoepitope peptide vaccine at the University Hospital Mannheim.

T cells are critical for maintaining human health by eliminating tumor cells from the body – a process that is driven by the specific interaction of unique receptors on the surface of T cells (T cell receptors or TCRs) to mutant peptides (antigens) on the surface of tumor cells. The identification of such cancer-specific antigens and the TCRs that bind them underlies current efforts to develop targeted cancer therapies. Until now, functionally robust high-throughput approaches to this challenge were lacking.

Dr. John M. Lindner and his research team at the BioMed X Institute in Heidelberg designed the T-FINDER platform to solve this problem. The platform, published now in Science Advances, is capable of rapidly screening thousands of potential interactions between TCRs and antigens on the surface of potential target cells for their ability to activate T cells. Driven by a trio of lead scientists (Miray Cetin, Dr. Veronica Pinamonti, and Dr. Theresa Schmid), the team first generated a highly sensitive reporter cell line for T cell activation. This reporter lies at the heart of T-FINDER, which can sensitively read out the specificity of any number of T cell-activating receptors (for example, CAR-T receptors in addition to classical TCRs) and ligands. For the latter, Dr. Pinamonti provided solutions to key aspects of enabling the detection of class II HLA-presented peptides during her PhD thesis work, leading to the development of novel strategies for boosting antigen processing and presentation by the target cell. This class of ligand was, until now, very challenging to investigate experimentally and together with its superior sensitivity form the foundation of T-FINDER’s advantages in the field.

In a companion manuscript also appearing today, the team collaborated with a research team led by Dr. Ed Green from the Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology (Head: Prof. Michael Platten) at DKFZ and University Hospital Mannheim. The researchers applied T-FINDER to decode the immune response of two diffuse midline glioma patients vaccinated against the H3 mutation that was driving their cancer. Patients receiving the H3-vaccine have shown promising but heterogeneous results, and with the aid of T-FINDER, the two groups could precisely map the functional immune response of a patient in remission to TCRs binding HLA class II-presented epitopes of mutant H3. This work provides key insights into the mechanism of anti-tumor T cell responses in these patients and will support ongoing vaccination studies.

"We are excited about the publication of the results of our collaboration with Ed Green, Michael Platten, and colleagues," said John Lindner, Head of Immunology Discovery at the BioMed X Institute. "Our joint research demonstrated the unique sensitivity, flexibility, and overall performance of our new T-FINDER platform, especially for class II HLA-presented targets, which have always been a challenge in the past."

"Previously, we have been limited in the tools we could use to study class II-presented epitopes such as mutant H3. The T-FINDER platform has enabled us to identify and benchmark dozens of H3-reactive TCRs, allowing us to track patient responses to vaccination today, as well as benchmark TCRs for the autologous cell therapies of tomorrow," said Ed Green, Head of the ImmunoGenomics team in Michael Platten’s lab at the DKFZ.

About BioMed X

BioMed X is an independent research institute with sites in Heidelberg, Germany, New Haven, Connecticut, XSeed Labs in Ridgefield, Connecticut, and a worldwide network of partner locations. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds – academia and industry – and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.

About Universitätsmedizin Mannheim

The Universitätsmedizin Mannheim (UMM) stands for quality-assured maximum care, research and teaching. As one of the largest university medical institutions in the Metropolitan Region Rhine-Neckar, it unites two strong partners – the Medical Faculty Mannheim of the renowned Heidelberg University and the University Hospital Mannheim. Every year, the University Hospital offers a wide range of state-of-the-art diagnostics and treatment procedures to around 45,000 inpatients and day patients as well as 170,000 outpatients. In 30 specialist clinics and institutes, around 5,500 employees are involved in patient care, research and teaching at the hospital and the faculty. The Medical Faculty is a recognized partner of renowned research institutions and is currently training around 1,950 medical students in its successful model programme MaReCuM. The scientific profile is shaped by the four main research focus areas of Vascular Biology and Medicine, Oncology, Translational Neurosciences and Medical Systems Technologies.

Contact Information

Flavia-Bianca Cristian
Recruiting & Communications Manager
fbc@bio.mx
+49 6221 426 11 706

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SOURCE: BioMed X Institute

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View the original press release on newswire.com.

More Surf Pools Coming to Brazil as AWM and Real Estate Developer JHSF Ink Exclusive License

PerfectSwell® Proven Anchor in Real Estate Development

SOLANA BEACH, CA / ACCESSWIRE / February 6, 2024 / American Wave Machines, the global leader in world class surf pool destinations, today announced a multi-year exclusive national license agreement with JHSF, Brazil’s leading high- end real estate development company. The agreement grants JHSF exclusivity to the PerfectSwell® brand and technology portfolio in Brazil, partnering AWM with Brazil’s most prominent real estate development group. Springing from the success of Boa Vista Village, JHSF’s first PerfectSwell® project, and the imminent opening of São Paulo Surf Club, the agreement primes both companies for continued growth in this emerging sector.

"JHSF is constantly innovating its portfolio, aimed at clients who are motivated first and foremost by quality and excellence. Together JHSF and AWM have proven PerfectSwell and Real Estate have complete synergy in delivering a unique experience with quality and excellence. Our clients catch perfect waves and create lasting memories all in their own communities," said JHSF CEO, Thiago Alonso de Oliveira. "PerfectSwell® is the leading brand in this space making it a great partnership and a key offering for our clients."

"We’re stoked to extend our strategic partnership with JHSF and continue adding to the legacy of surfing excellence in Brazil. The Brazilian Storm is real, JHSF and their clients are champions for surfing in more ways than one," said Bruce McFarland, CEO of AWM. "PerfectSwell® projects on the horizon in Brazil are nothing short of world class and we will continue delivering our highest tier specification at each new location with JHSF creating world class surf experiences."

About American Wave Machines

American Wave Machines, Inc.is the inventor and developer of PerfectSwell® Surf Technology. AWM’s technology powers world class surf facilities and destinations backed by proven financials, extensive data capture, and stoked surfers. PerfectSwell® is the only sequence based, pneumatic surf technology on the market. Protected by over 50 patents worldwide, PerfectSwell® Split Peaks, Peeling Waves, Air Sections, and Wedge Barrels are all covered by AWM’s robust patent portfolio.

About JHSF

JHSF is a Brazil-based holding company and leader in the high-income real estate industry in Brazil, engaged in real estate development, shopping mall and fashion retail and hospitality and gastronomy. Founded in 1972, the company’s main area of operation and investment is in the high-income segment, with a focus on recurring income activities. The company, which has been publicly traded since 2007 and has its shares listed on B3’s Novo Mercado, operates in both the Brazilian market and other countries, such as the United States and Uruguay. It was the first company in the Brazilian real estate sector to prioritize recurring income assets, including the operation of shopping centers, an airport, and hotels, in addition to real estate projects. For more information visit jhsf.com.br

Contact:

Jenna Timinsky
info@americanwavemachines.com

SOURCE: American Wave Machines, Inc.

View the original press release on accesswire.com

More Surf Pools Coming to Brazil as AWM and Real Estate Developer JHSF Ink Exclusive License

PerfectSwell® Proven Anchor in Real Estate Development

SOLANA BEACH, CA / ACCESSWIRE / February 6, 2024 / American Wave Machines, the global leader in world class surf pool destinations, today announced a multi-year exclusive national license agreement with JHSF, Brazil’s leading high- end real estate development company. The agreement grants JHSF exclusivity to the PerfectSwell® brand and technology portfolio in Brazil, partnering AWM with Brazil’s most prominent real estate development group. Springing from the success of Boa Vista Village, JHSF’s first PerfectSwell® project, and the imminent opening of São Paulo Surf Club, the agreement primes both companies for continued growth in this emerging sector.

"JHSF is constantly innovating its portfolio, aimed at clients who are motivated first and foremost by quality and excellence. Together JHSF and AWM have proven PerfectSwell and Real Estate have complete synergy in delivering a unique experience with quality and excellence. Our clients catch perfect waves and create lasting memories all in their own communities," said JHSF CEO, Thiago Alonso de Oliveira. "PerfectSwell® is the leading brand in this space making it a great partnership and a key offering for our clients."

"We’re stoked to extend our strategic partnership with JHSF and continue adding to the legacy of surfing excellence in Brazil. The Brazilian Storm is real, JHSF and their clients are champions for surfing in more ways than one," said Bruce McFarland, CEO of AWM. "PerfectSwell® projects on the horizon in Brazil are nothing short of world class and we will continue delivering our highest tier specification at each new location with JHSF creating world class surf experiences."

About American Wave Machines

American Wave Machines, Inc.is the inventor and developer of PerfectSwell® Surf Technology. AWM’s technology powers world class surf facilities and destinations backed by proven financials, extensive data capture, and stoked surfers. PerfectSwell® is the only sequence based, pneumatic surf technology on the market. Protected by over 50 patents worldwide, PerfectSwell® Split Peaks, Peeling Waves, Air Sections, and Wedge Barrels are all covered by AWM’s robust patent portfolio.

About JHSF

JHSF is a Brazil-based holding company and leader in the high-income real estate industry in Brazil, engaged in real estate development, shopping mall and fashion retail and hospitality and gastronomy. Founded in 1972, the company’s main area of operation and investment is in the high-income segment, with a focus on recurring income activities. The company, which has been publicly traded since 2007 and has its shares listed on B3’s Novo Mercado, operates in both the Brazilian market and other countries, such as the United States and Uruguay. It was the first company in the Brazilian real estate sector to prioritize recurring income assets, including the operation of shopping centers, an airport, and hotels, in addition to real estate projects. For more information visit jhsf.com.br

Contact:

Jenna Timinsky
info@americanwavemachines.com

SOURCE: American Wave Machines, Inc.

View the original press release on accesswire.com

Be sure before sharing: Is it true that single women are at risk of blood clots because of ovarian cancer?


On social media, the article was shared. ‘Surgeon warns! Single female patient case She had confused speech and brain death. Finally, she was diagnosed with ovarian cancer. It can cause blood clots in various organs.’

?? Check with Prof. Dr. Sarukphan Wilailak, Department of Obstetrics-Gynecology. Faculty of Medicine Ramathibodi Hospital Mahidol University

This group of information is real information. And there are still parts that need to be added in more detail. Therefore able to understand correctly and completely

Single women have a higher risk of ovarian cancer than unmarried women?

Are single women more likely to get ovarian cancer?

It was found that there was not a very significant relationship.

Single or unmarried women have a chance of developing ovarian cancer. The incidence is similar. Not clearly different It’s just that if the ovaries are rested for a long time, it will be found that the incidence decreases a bit, such as having multiple pregnancies.

women without children The ovaries ar
e not used. Are there a greater chance of developing ovarian cancer than women who have children?

‘Using the Ovaries’ This issue is interesting. We have to invite you to think about what the ovaries have or function.

The ovaries have two important jobs.

Task 1 : Create female hormones

Task 2 : Create eggs for maturation and fertilization.

Therefore, every woman has already used her ovaries. Even if you have children or not.

Feeling confused, unable to speak caused by brain death Because it is ovarian cancer?

Confused speech is also a symptom of brain death or lung tissue death. Difficulty breathing, not being able to breathe, and losing oxygen is also possible. These symptoms can occur with any type of cancer. Because of the nature of cancer, it can easily cause blood clots.

Any lump, such as colon cancer or ovarian cancer, has a large lump in the abdomen or pelvic area that presses on, causing blood to return to the heart or blood flow inconveniently. Blood clots can easily form. The blood clot sprea
ds to block important organs, most commonly the brain and lungs, causing symptoms of brain death in patches.

Being single or not is not related to blood clots and other symptoms.

Asked if single or not single about having a blood clot in the brain. Or is the blood clot blocking another organ? was not found to be relevant But it is more risky behaviors that cause blood clots.

If the ovaries are used too much Change sleeping partners frequently Will I be at risk for cervical cancer?

Women who frequently change sexual partners do not necessarily mean that their ovaries are overactive.

Changing sexual partners frequently increases the risk of cervical cancer. Because there is a chance of getting more strains of HPV virus, which causes cervical cancer, into the body.

For older women The ovaries are rarely used. It is recommended to see an obstetrician-gynecologist. Regular health check-ups or internal examinations Because the chance of having abnormalities such as tumors or gynecological cancers is higher.

As for what was shared: ‘A single woman has symptoms of confused speech, is brain dead, and is finally diagnosed with ovarian cancer. It can cause blood clots in various organs.’

This information is partly true. And then there are parts that still need to be further clarified to be correct and complete. Otherwise, there will be misunderstandings regarding ovarian cancer.

Interview by Peeraphon Anutarasothi

Compiled by Komsthanon Sukajjasakul

See more items Be sure before sharing: Is it true that single women are at risk of blood clots because of ovarian cancer ?

Source: Thai News Agency

‘Amazing Muay Thai Day, famous all over the world’ for the year 2024


Feb. 6, 2024, the Royal Thai Army organized a grand event “Amazing Muay Thai Day, Famous to the World” for the year 2024, Amazing MuayThai World Festival 2024.

As the government has designated February 6th of every year as ‘Thai Boxing Day’ which is the day of the accession to the throne of King Sanphet VIII or ‘King Suea’, he was skilled in Thai boxing. In order to pass on the art of Muay Thai to future generations. It is also a valuable cultural heritage of the Thai nation until the present. The Royal Thai Army therefore sees the importance of Mae Mai Muay Thai is not just a martial art. But if it is an expression of arts, culture, customs, identity of the Thai nation. Therefore, it has been carried out in collaboration with the Tourism Authority of Thailand (TAT), Sports Authority of Thailand (SAT), Ministry of Culture. Government agencies Private sector agencies and Prachuap Khiri Khan Province Jointly organize the “Amazing Muay Thai Day, Famous to the World” for the year 2024 “Amazing MuayThai World Fe
stival 2024” from February 4-6, 2024 from 4:00 p.m. – 10:00 p.m. every day at Rajabhakti Park, Hua Hin District. Prachuap Khiri Khan Province The objective is to promote Thai boxing as a national sport. and Thai national heritage published history Inscribed with beautiful and international cultural traditions To make the sport of Muay Thai known around the world. and to expand cultural tourism by using Muay Thai as the medium Let Rajabhakti Park be the home of Muay Thai that Thai people and tourists must come to.

Today (February 6, 2024) at 5:45 p.m., Mr. Settha Thavisin, Prime Minister, has the honor of presiding over the official event under the name “Amazing Muay Thai Day, Famous to the World” for the year 2024, along with Mr. Anutin. Charnvirakul, Deputy Prime Minister and Minister of Interior, Mr. Suthin Klangsaeng, Minister of Defense, Mr. Sermsak Phongphanich, Minister of Culture, Ms. Sudawan Wang Suphakit Koson Minister of Tourism and Sports Honored to work together As for the Army, there is General
Charoenchai Hinthao, Commander-in-Chief of the Army. Along with the high commanders to welcome

Activities include Placing a wreath of fresh flowers to pay homage to the royal monuments of the 7 First Kings of Siam, to pay homage to the statue of King Sanphet VIII (King Suea), and to pay homage to the royal portrait of His Majesty the King. Number 10: Receive auspiciousness from Phan Phum. Giving auspicious blessings to senior boxing teachers Then enter 3 sets of performances, including set 1 ‘Amazing Muay Thai From the roots of Siam Thai Martial Arts Heritage to the World’ Set 2 ‘Ancient Traditions surrender to disciple Teacher recruitment and teacher tenure The magic of Muay Thai culture’ and the third set ‘Investigating the art of the Wai Khru dance, the Mae Mai Muay Thai, to the letter-transforming drone. Spectacular Lights’ with more than 3,000 Royal Thai Army personnel participating in the Wai Khru Ceremony, together with boxers from the King Suea Boxing Association and the people, a total of more than
5,000 people, along with lettering using more than 700 letter-writing drones and Firework display To show the importance and greatness of the work

.

Source: Thai News Agency

Arrest of “Beam Chaika” who tricked victims into spending the night before secretly stealing their belongings and fleeing.


Bangkok, Metropolitan Police detectives arrested “Beam Chaika” who was accused of tricking the victim into sleeping with him. Then secretly stole the property and fled. Examination found that the accused had acted in this manner many times. Earn a lot of money and valuables. And there are many other victims who do not dare to report crimes.

The Metropolitan Police worked together to arrest him. Ms. Phattharaphon, age 23, was arrested in front of the condo. Soi Ramkhamhaeng 43/1 Wang Thonglang District, Bangkok, for the crime of “stealing at night, taking any documents of another person and illegally use another person’s electronic card which was issued to the authorized user. To use to withdraw cash In a way that is likely to cause damage to others or the public.’

In this case, the circumstances were that the accused would wander around at night looking for victims in entertainment venues in Bangkok when he met the victim at a restaurant. and exchanged Line IDs The accused arranged to meet the victim at th
e victim’s room, pretending to ask to stay overnight. When the opportunity arose while the victim went to the bathroom and accidentally took the victim’s property, such as a gold necklace, gold ring, ATM card.

From the interrogation, it was found that there were many other acts of this nature. Received money and valuables approximately 20,000-40,000 baht per time, and there were still many victims. But shame often arises. Not daring to report the crime Because they fear it will be in the news and have an impact on the family. After that, he was detained and transported to Phahon Yothin Police Station for further legal proceedings.

Source: Thai News Agency

Expelling an obscene computer teacher and 3 female students from school.


Nakhon Sawan, Villagers in Tha Tako District, Nakhon Sawan Province, protested to expel a “computer teacher” from the school after he sexually assaulted three female students. Recently, the school has severely punished him and has removed him from government service.

Yesterday (Feb. 5), father and mother took Miss Kluay (pseudonym), age 10, a Grade 4 student, to report at Tha Tako Police Station, Tha Tako District, Nakhon Sawan Province, so that legal action could be taken against the teacher. Teach computers, music and art at a school in Tha Tako District, charged with sexual harassment. Inside the classroom The incident occurred in the afternoon of January 29th.

The mother of Miss Kluai (pseudonym) said that the matter became red because her daughter told her brother about the teacher’s actions. Before my brother came to tell me again. Therefore, he had to hurry and ask his daughter very hard. After listening to the whole story, he became angry because he could not accept that the teacher was abusing his
daughter. Not just once But it’s been done before. Since my daughter was in Grade 3 in the first semester, and it wasn’t just my daughter who was treated like this. Because there were two other female students who were treated in the same way. So he took his daughter to report the matter on February 1st. Today (February 6th), he brought his daughter to give additional information to the police. before being taken for questioning by a multidisciplinary team It is learned that two more parents of children who were subjected to the same type of treatment will also report to the police today.

As for Miss Kluai’s father (pseudonym), he insists that he will take the matter to the end. Teachers like this should absolutely not be left alone. Because this kind of action made my daughter so afraid that she didn’t dare go to school.

As for the parents of two girls who were sexually abused by teachers, they brought their daughters to report to the police earlier. One of them, the daughter of Ms. Irin (pseudonym), aged
37, revealed that she was harassed by a bald, glasses-wearing teacher by touching her breasts. Until the daughter had to escape quickly and tell her mother. And the daughter is also a classmate with Miss Kluai (pseudonym). The other girl is known to have been violated by touching her genitals. So they want this physical education teacher to go to jail.

Pol. Col. Issaret Handam, superintendent of Tha Tako Police Station, gave information that he had been notified about this matter since February 1st. Two parents of the girl have brought their daughters to report the matter. Today, another person has been reported and is currently being investigated. Collaborate with multidisciplinary and social development Therefore, no charges have been filed at this time. The teacher at the school who was accused was aware that he had contacted the police. He will request to surrender himself to fight the case tomorrow (Feb. 7), but if he does not come as scheduled, a summons will be issued first. And if the summons still d
oes not appear, an arrest warrant will be issued. But as far as we know right now, the said teacher is still in the area. Didn’t escape anywhere

The reporter traveled to the school. which is the parent school of the teacher who was reported It was revealed from the school director that after knowing about the matter The school immediately set up a committee to investigate the facts. And now the said teacher has been released from teaching status at this school for the time being. If found to have committed an offense as alleged, punishment will be carried out according to government regulations. As for the students who were treated The school is not complacent. The school has provided relief, comfort and encouragement to the three students who were treated.

Source: Thai News Agency

dried starfish Along the Ubonrat Dam, selling well creates income for the community.


Nong Bua Lamphu, Catching the eye of travelers with dried starfish. Processed fish products From the Pla Tha Sila village community, OTOP products are famous for selling well in the district. It is a freshwater fish from Ubonrat Dam, Non Sang District, Nong Bua Lamphu Province. Sells well and creates income for the community

Mr. Samai Mothong, Village Headman, Village No. 6, Ban Kho Subdistrict, Non Sang District, Nong Bua Lamphu Province has given information that There are 25 shops in the community that sell fish. Fish is a famous product of the village. They are processed to sell well, including dried fish, orange fish, and fresh fish. And fish products from this village can be guaranteed and assured that they are clean, fresh fish every day. On average, selling fish generates income of 20,000 baht per household per month.

The fish processing method that is the identity of the village is dried starfish They will bring various types of fish such as catfish, catfish, goby, tilapia, carp, catfish, or fish
caught during that time. When the fish were brought up from Ubonrat Dam The fish scales are scraped off, cleaned, seasoned and then dried in the sun. When the fish is dried, it is strung into circles or ovals, resembling a star.

In addition, there is also making som fish. which is another famous product The steps for making it are removing fish scales, cleaning, seasoning and mixing with the village’s special seasoning recipe. Most consumers will steam or bake them. There is also fresh fish for sale from Ubonrat Dam. It also creates income for the household. The Ban Tha Sila fish community is open for sale every day. Located in Village No. 6, Ban Kho Subdistrict, Non Sang District, Nong Bua Lamphu Province. Close to Phu Aen Skywalk.

Source: Thai News Agency