Day: July 26, 2023

PHILADELPHIA, PA, July 26, 2023 (GLOBE NEWSWIRE) — It’s been known since the 1960s that Epstein-Barr Virus (EBV) causes a variety of cancers, but research has overwhelmingly focused on its connection to lymphomas. Now, a multidisciplinary team of scientists led by The Wistar Institute has been awarded a more than $12 million National Cancer Institute (NCI) Program Project Grant (P01), a highly competitive five-year grant that includes a crosssection of researchers from various disciplines and institutions throughout the country. The multidisciplinary team led by Wistar scientists is exploring the role of Epstein-Barr Virus in epithelial cancers. Epithethelial cells form functional structures in organ tissue throughout the human body; they are often the site for solid organ cancers, including the most common cancers, which are known as carcinomas.

The new research will focus on basic questions about how EBV infection of normal epithelial cells transforms them into cancer-cells. Scientists also intend to build on this research to identify better and more selective therapeutic targets.

“We are investigating unexplored aspects of EBV and malignancies, potentially uncovering unique characteristics or pathways that can be targeted for therapeutic intervention,” said Italo Tempera, Ph.D., associate professor of the Gene Expression & Regulation Program of the Ellen and Ronald Caplan Cancer Center at The Wistar Institute. “This fresh perspective could lead to groundbreaking discoveries and innovative treatment strategies for EBV and epithelial malignancies.”

The project brings together scientists from The Wistar Institute and Harvard University, including experts in epigenetics, metabolomics and drug discovery. It’s the first time researchers from this variety of disciplines have combined their efforts to focus entirely on the EBV-epithelial cancer link.

“We’ve put together a new strategy, a new way of attacking the problem,” said Paul Lieberman, Ph.D., Hilary Koprowski, M.D., Endowed Professor and director of the Center for Chemical Biology and Translational Medicine at Wistar. “By working together across different modalities, there’s an opportunity for each of us to learn from the synergy and expertise of the other investigators.”

EBV is one of the most common human viruses, infecting an estimated 95% of people by the time they reach adulthood. Symptoms are usually mild, and most people recover within a few weeks. However, the virus can remain latent in the human body for years or even decades, and it causes some people to develop cancer later in life.

While research has historically focused on lymphomas, EBV-linked epithelial cancers are both more common and more deadly. Epithelial cancers represent 75% of the 200,000 EBV-related cancer cases diagnosed each year, and these cancers also have higher mortality rates and treatment failures.

“This grant put together a team that is now focused on this type of cancer that has been neglected, even though it’s the most common form of EBV cancers,” Lieberman said. The grant will fund three main research projects. The first will look at how EBV establishes a long-term infection within epithelial cells. The second will study how it causes genetic and metabolic changes to trigger cancer growth. Finally, researchers will use these findings to investigate new therapeutic strategies.

The research builds on past work by Lieberman’s lab, which has focused on developing small molecule inhibitors targeting EBV. He said the new project would focus on studying drugs that are already in development, and looking for ways to make them more targeted or use them in combination with other therapies.

Tempera said the group’s integrated approach sets it apart.“Our project will study both metabolic and epigenetic vulnerabilities simultaneously,” he said. “Combining these two aspects can provide a comprehensive understanding of the role of EBV infection in cancer and its underlying mechanisms, leading to unique insights and therapeutic opportunities.”

Co-authors: Ben Gewurz of Harvard; Joseph Salvino, Samantha Soldan, Andrew Kossenkov, Louise Showe, and Qin Liu of Wistar.

Darien Sutton
The Wistar Institute
215-870-2048
dsutton@wistar.org

GlobeNewswire Distribution ID 8881269

Airshare Continues Growth, Plans to Double Fractional Challenger Fleet with New Agreement Featuring Bombardier’s Challenger 3500 Aircraft

Airshare plans to double its Challenger fleet

• Airshare commits to ordering up to 20 additional¹ Challenger 3500 super-midsize jets
• Order builds on previous commitment for up to 20 Challenger aircraft initially announced in May 2021
• The best-selling Challenger 3500 aircraft continues to impress with its ultimate combination of refined cabin experience, proven reliability and top performance
• One of the fastest-growing private aviation companies in the United States, Airshare has experienced heavy demand for the Challenger platform among fractional customers, fulfilling their need to travel coast-to-coast while enjoying best-in-class comfort

MONTREAL, July 26, 2023 (GLOBE NEWSWIRE) — Bombardier today announced that Kansas City-based private aviation company Airshare has committed to ordering up to 20 additional Challenger 3500 aircraft. Through this new agreement, Airshare plans to double the size of their Challenger fleet, supporting the considerable demand they have experienced from the outset of launching the aircraft within their fractional program.

In May 2021, Airshare entered the super-midsize segment with an order for up to 20 Challenger aircraft. As the fast-growing private aviation company moves to exercise all options as part of that original order, this new incremental commitment to Challenger 3500 jets underscores that the smooth, efficient and reliable customer experience that private aviation provides continues to garner significant market interest among the travelling public.

“The response we have received to the Challenger entering our fractional program has been tremendous, from both new and existing customers,” said John Owen, President and Chief Executive Officer of Airshare. “We are thrilled to extend our commitment with Bombardier and look forward to adding several more Challenger 3500s to our fleet. The strength of our partnership made it easy for us to accelerate our plans to order more of these aircraft to meet customer demand.”

“The entire team is immensely proud that Airshare continues to trust Bombardier to grow its fleet,” said Eric Martel, President and Chief Executive Officer, Bombardier. “Airshare and Bombardier share several values ​​in common: we strive for excellence and work tirelessly to offer an exceptional experience to our clients. With this new order, our valued relationship continues to grow stronger, as the award-winning Challenger 3500 aircraft keeps elevating Airshare’s flight experience with its ultimate combination of performance and comfort.”

Airshare’s fractional program provides each owner of a 1/16th share with 20 days and unlimited flight time (based on a customer’s allocation of days with a maximum 14-hour crew duty day). When Airshare shareowners begin and end in the same location, while keeping the aircraft and crew with them when they need it, they save up to 25 per cent off their hourly rate. Having the pilots and aircraft stay with shareowners as they travel provides the ultimate in flexibility as they are able to visit multiple locations and adjust their schedules at a moment’s notice. Airshare also offers its own jet card program, EMBARK, as well as aircraft management, on-demand charter and maintenance services.

Built on the iconic Challenger super mid-size platform, the Challenger 3500 aircraft offers unrivalled comfort and reliability, while boasting top performance and delivering Bombardier’s signature smooth ride. The latest addition to Bombardier’s portfolio elevates the passengers’ experience by integrating many of the features from Bombardier’s Global family of aircraft, including Bombardier’s exclusive and revolutionary Nuage seat. Passengers can also benefit from the ultimate cabin experience, where technology and design come together to maximize productivity while offering a refined and relaxing environment.

The Challenger 3500 aircraft is also the most sustainably designed business jet in its class. It is the first business jet in the super mid-size segment to have an Environmental Product Declaration published, documenting the aircraft’s environmental footprint over its lifecycle.

The Challenger aircraft family is known for its industry-leading reliability and safety. With over 900 business jets of the Challenger 300 series in service worldwide, the Challenger 3500 aircraft builds on the excellent track record of the Challenger family and boasts an impressive 99.8% dispatch reliability.

About Airshare

Airshare fits the way you fly. Founded in 2000 and headquartered in Lenexa, Kan., the company offers a holistic suite of private aviation solutions including fractional ownership, jet cards, whole aircraft management charter services and third-party maintenance. Airshare operates a fleet of super-midsize and light jets within their fractional and EMBARK jet card programs to customers across the central United States and Florida. The company provides whole aircraft management and charter services nationwide, while also performing comprehensive maintenance services for third-party aircraft. Airshare has received IS-BAO Stage 3 and ARGUS Platinum designations, meeting the highest international standards for safe flight operations. For more information visit www.flyairshare.com.

About Bombardier

Bombardier (BBD-B.TO) is a global leader in aviation, focused on designing, manufacturing, and servicing the world’s most exceptional business jets. Bombardier’s Challenger and Global aircraft families are renowned for their cutting-edge innovation, cabin design, performance, and reliability. Bombardier has a worldwide fleet of approximately 5,000 aircraft in service with a wide variety of multinational corporations, charter and fractional ownership providers, governments, and private individuals. Bombardier aircraft are also trusted around the world in government and military special-mission roles leveraging Bombardier Defense’s proven expertise.

Headquartered in Greater Montréal, Québec, Bombardier operates aerostructure, assembly and completion facilities in Canada, the United States and Mexico. The company’s robust customer support network services the Learjet, Challenger and Global families of aircraft, and includes facilities in strategic locations in the United States and Canada, as well as in the United Kingdom, Germany, France, Switzerland, Italy, Austria, the UAE, Singapore, China and Australia.

For corporate news and information, including Bombardier’s Environmental, Social and Governance report, as well as the company’s plans to cover all its flight operations with Sustainable Aviation Fuel (SAF) utilizing the Book and Claim system visit bombardier.com. Learn more about Bombardier’s industry-leading products and customer service network at businessaircraft.bombardier.com. Follow us on Twitter @Bombardier.

Bombardier, Challenger, Challenger 3500, Global and Nuage, are registered or unregistered trademarks of Bombardier Inc. or its subsidiaries.

For information
Bombardier
Christina Lemyre McCraw
Manager, Public Relations and Communications
+1 514 497-4928
christina.lemyremccraw@aero.bombardier.com

Airshare
Andy Tretiak
Chief Marketing Officer
816-410-8135
atretiak@flyairshare.com

¹ The agreement includes a firm order for 4 Challenger 3500 aircraft and an option for 16 additional Challenger 3500 business jets.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/dbdeecf6-fa80-49c2-bcee-aa1e622c9e0a

GlobeNewswire Distribution ID 8880965

HVDC interconnection to secure power transmission and support new renewable electricity generation with the country’s largest electricity transmission project

Zurich, Switzerland, July 26, 2023 (GLOBE NEWSWIRE) — Hitachi Energy, a global technology leader that is advancing a sustainable energy future for all, today announced it has been selected as preferred technology provider of SSEN Transmission and National Grid, to supply two high-voltage direct current (HVDC) converter stations to interconnect the Scottish and English power grids.

The energy transition requires a collaborative effort that can only be achieved with advanced technologies and new ways of working. In appointing Hitachi Energy as their preferred technology provider, SSEN Transmission and National Grid secure best-in-class technology and future production capacity in a rapidly growing market. For Hitachi Energy, this enables investment in new production capacity and to undertake large-scale recruitment drives. It also strengthens collaboration, standardization of solutions, and synergies between projects.

The integration of renewables requires solutions that make the grid resilient, stable, and flexible. Hitachi Energy’s innovation and long development of voltage sourced converter (VSC) power electronics and control and protection (MACH) technologies meet the requirements alongside many other landmark grid integration projects.

Eastern Green Link 2 will consist of two 525-kilovolt (kV) bipole VSC converter stations connected by 440 kilometers of subsea cable and 70 kilometers of underground cable, making it the longest HVDC link in the UK. The link will efficiently supply a total of 2,000 megawatts (MW) of electricity, which is enough to power around two million UK homes.¹

The link will help to secure power transmission in the northern UK and support the integration of new renewable electricity generation in Scotland, as part of the UK’s Net Zero Strategy.² As much as 11,000 MW of offshore wind capacity is possible in Scottish waters by 2030³, and HVDC transmission will play a large part in bringing this vast amount of renewable power to shore and south, to communities across the country.

“The UK’s Net Zero Strategy has ambitious targets which will require vast amounts of new renewable generation. Electricity will be the backbone of the entire energy system,” said Niklas Persson, Managing Director at Hitachi Energy’s Grid Integration business. “Our pioneering HVDC technology will ensure that this electricity will reliably and efficiently get where it’s needed most.”

“This is another important milestone for EGL2 which is part of the new network infrastructure required to help the UK meet its net zero and energy security ambitions,” said Sarah Sale, Deputy Project Director of National Grid. “Along with cabling bidder and formal joint venture announcements, this is another key part of the project which is now in place and ready for the delivery phase. We look forward to working in collaboration with Hitachi Energy and BAM as the project continues to progress.”

“The converter stations at either end of the cable will play a crucial role in making the power transported subsea suitable for transportation around the onshore transmission network – getting Hitachi Energy and BAM in place to deliver that technology is great for the project,” said Ricky Saez, the EGL2 Project Director from SSEN Transmission.

“BAM is delighted to work in collaboration with Hitachi Energy on this vital renewable energy project for National Grid and SSEN Transmission,” said Huw Jones, Executive Director of BAM Nuttall. “The converter stations will enable the transmission of green energy from areas of offshore wind generation to centers of population, supporting the UK’s net zero ambitions and providing better energy security. We look forward to engaging with local communities and suppliers in Aberdeenshire and North Yorkshire, supporting BAM’s vision to deliver sustainable infrastructure for our clients, stakeholders, and the communities in which we work.”

Hitachi Energy is collaborating with BAM, a construction company that designs, builds, and maintains sustainable buildings and infrastructure, to provide the civil and installation scope for the project. The collaboration with BAM will leverage the core competencies of the two companies to deliver a best-in-class solution for the project.

Hitachi Energy pioneered commercial HVDC technology almost 70 years ago and has delivered more than half of the world’s HVDC projects.

1 https://www.nationalgrid.com/electricity-transmission/network-and-infrastructure/segl2
2 https://www.gov.uk/government/publications/net-zero-strategy
3 https://www.gov.scot/publications/offshore-wind-policy-statement/
4 Modular Advanced Control for HVDC (MACH)

HVDC website:

https://www.hitachienergy.com/offering/product-and-system/hvdc

Photo captions:

North Sea Link Blyth Converter Station UK

Eastern Green Link 2

About Hitachi Energy
Hitachi Energy is a global technology leader that is advancing a sustainable energy future for all. We serve customers in the utility, industry and infrastructure sectors with innovative solutions and services across the value chain. Together with customers and partners, we pioneer technologies and enable the digital transformation required to accelerate the energy transition towards a carbon-neutral future. We are advancing the world’s energy system to become more sustainable, flexible and secure whilst balancing social, environmental and economic value. Hitachi Energy has a proven track record and unparalleled installed base in more than 140 countries. Headquartered in Switzerland, we employ around 40,000 people in 90 countries and generate business volumes of over $10 billion USD.
https://www.hitachienergy.com
https://www.linkedin.com/company/hitachienergy
https://twitter.com/HitachiEnergy

About Hitachi, Ltd.

Hitachi drives Social Innovation Business, creating a sustainable society through the use of data and technology. We solve customers’ and society’s challenges with Lumada solutions leveraging IT, OT (Operational Technology) and products. Hitachi operates under the business structure of “Digital Systems & Services” – supporting our customers’ digital transformation; “Green Energy & Mobility” – contributing to a decarbonized society through energy and railway systems, and “Connective Industries” – connecting products through digital technology to provide solutions in various industries. Driven by Digital, Green, and Innovation, we aim for growth through co-creation with our customers. The company’s consolidated revenues for fiscal year 2022 (ended March 31, 2023) totaled 10,881.1 billion yen, with 696 consolidated subsidiaries and approximately 320,000 employees worldwide. For more information on Hitachi, please visit the company’s website at https://www.hitachi.com.

Attachments

• Hitachi Energy selected as preferred technology provider for the longest HVDC link in the UK
• Hitachi Energy selected as preferred technology provider for the longest HVDC link in the UK

Jocelyn Chang
Hitachi Energy
jocelyn.chang@hitachienergy.com

GlobeNewswire Distribution ID 8881044

คุนหมิง จีน, July 26, 2023 (GLOBE NEWSWIRE) — Yunnan Innyo Co., Ltd. และ @visityunnan ได้เปิดตัวชุดวิดีโอที่นำเสนอความงามอันน่าทึ่งของถนนชาม้าโบราณ การเปิดตัววิดีโอเหล่านี้ได้รับความสนใจจากผู้ชมทั่วโลก มรดกทางประวัติศาสตร์และวัฒนธรรมที่ลึกซึ้งของถนนชาม้าโบราณได้ดึงดูดจินตนาการของผู้ชมนับไม่ถ้วนที่มีความกระหายที่จะสำรวจเสน่ห์แห่งถนนสายนี้

เสน่ห์อย่างหนึ่งของถนนชาม้าโบราณนั้นอยู่ที่หมู่บ้านโบราณ ด้วยสถาปัตยกรรมที่ได้รับการอนุรักษ์ไว้เป็นอย่างดีและบรรยากาศที่มีเสน่ห์ ทำให้หมู่บ้านเหล่านี้มีกลิ่นอายของอดีต วิดีโอชุดนี้เน้นความสำคัญทางประวัติศาสตร์และความรุ่มรวยทางวัฒนธรรมของหมู่บ้านเหล่านี้ และนำผู้ชมไปสู่ยุคอดีตและดึงดูดผู้ชมด้วยเสน่ห์ที่ไร้กาลเวลา

ขุนเขาแห่งใบชาทั้งหกแห่งบนถนนชาม้าโบราณเป็นอีกแง่มุมหนึ่งที่น่าตื่นตาซึ่งดึงดูดความสนใจของผู้ชม วิดีโอชุดนี้แสดงภูมิประเทศที่สวยงามซึ่งประดับประดาไปด้วยไร่ชาอันเขียวขจี และให้ภาพอันสวยงามแก่ผู้ชม มรดกแห่งการปลูกชาและความงามตามธรรมชาติของภูเขาเหล่านี้ทำให้ผู้ชมประหลาดใจ และทำให้ผู้ชมรู้สึกชื่นชมในความมหัศจรรย์ของภูมิภาคที่ไม่เหมือนใครแห่งนี้

วิดีโอเกี่ยวกับอาหารและทิวทัศน์ตามเส้นทางของถนนชาม้าโบราณนั้นได้ดึงดูดผู้ชมจำนวนมาก อาหารบนถนนชาม้าโบราณได้นำเสนอรสชาติและประเพณีของภูมิภาคที่เย้ายวนใจ ตั้งแต่อาหารที่มีรสชาติของชาไปจนถึงอาหารพิเศษประจำภูมิภาค ความงดงามของธรรมชาติและภูมิทัศน์ที่น่าอัศจรรย์ตลอดเส้นทางของถนนชาม้าโบราณนั้นได้ดึงดูดผู้ชมด้วยความโชติช่วงที่ไม่มีใครเทียบได้

โรงแรมบันชานมอบตัวเลือกที่พักที่ไม่เหมือนใคร สำหรับผู้ที่แสวงหาประสบการณ์พิเศษ โรงแรมตั้งอยู่ท่ามกลางภูมิประเทศที่สวยงาม โดยให้บริการสถานที่พักผ่อนอันเงียบสงบและดื่มด่ำสำหรับนักเดินทางที่มาสำรวจถนนชาม้าโบราณ

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GlobeNewswire Distribution ID 8880960