Daily Archives: January 15, 2019

SLN124 granted Orphan Drug Designation by EMA for the treatment of β-Thalassemia

SLN124 granted Orphan Drug Designation by EMA for the treatment of β-Thalassemia

January 15, 2019

LONDON, Silence Therapeutics, PLC (LON: SLN) (“Silence” or “the Company”) a leader in the discovery, development and delivery of novel RNA therapeutics for the treatment of serious diseases, announces that its lead medicine candidate SLN124 has been granted Orphan Drug Designation by the Committee for Orphan Medicinal Products (COMP), the European Medicines Agency’s (EMA) committee responsible for recommending orphan designations of medicines for rare diseases. This positive COMP decision has been adopted by the European Commission.

Following an application by Silence last year, the COMP concluded that SLN124 will be of significant benefit to those affected by the chronic and potentially life-threatening condition, β-Thalassemia. By receiving Orphan designation, SLN124 can benefit from expediated clinical development and ten years of market exclusivity, subject to approval. The COMP decision follows positive feedback from the UK Medicines and Healthcare products Regulatory Agency (MHRA) Scientific Advice meeting in June last year.

SLN124, which has been shown to lower serum iron levels and modulate tissue iron distribution in rodent models for β-Thalassemia and hereditary hemochromatosis, represents a promising therapeutic candidate for treating patients with iron overload disorders, including β-Thalassemia, myelodysplastic syndrome (MDS) and hereditary hemochromatosis.

Dr. David Horn Solomon, Chief Executive Officer of Silence Therapeutics, commented:
“We are pleased to receive Orphan Drug Designation for our iron overload disorder candidate, SLN124, which will assist in expediting clinical development as we progress our Phase Ib trial planned to begin in H2 2019. We believe that this innovative product offers significant promise for patients with iron overload disorders such as β-Thalassemia, MDS and hereditary hemochromatosis and we look forward to rapidly advancing SLN124 through clinical development.”

Enquiries:

Silence Therapeutics plc
Dr David Horn Solomon, Chief Executive Officer
Tel:  +44 (0)20 3457 6900
Peel Hunt LLP (Nominated Adviser and Broker)
James Steel/Oliver Jackson
Tel:  +44 (0)20 7418 8900
European IR
Consilium Strategic Communications
Mary-Jane Elliott / Angela Gray
silencetherapeutics@consilium-comms.com
Tel: +44 (0) 20 3709 5700
US IR
Westwicke Partners
Peter Vozzo
peter.vozzo@westwicke.com
 Tel: +1 (443) 213-0505

About Silence Therapeutics plc
Silence Therapeutics is developing a new generation of medicines by harnessing the body’s natural
mechanism of RNA interference, or RNAi, within its cells. Its proprietary technology can selectively
inhibit any gene in the genome, specifically silencing the production of disease-causing proteins. Using
its enabling delivery systems, it has achieved an additional level of specificity by delivering its
therapeutic RNA molecules exclusively to target cells. Silence’s proprietary RNA chemistries and
delivery systems are designed to improve the stability of our molecules and enhance effective delivery
to target cells, providing a powerful modular technology well suited to tackle life-threatening diseases.
For more information, please visit: https://www.silence-therapeutics.com/

CNH Industrial announces senior leadership change

London, January 15, 2019

CNH Industrial N.V. (NYSE: CNHI / MI: CNHI) announces that Pierre Lahutte is stepping down, with immediate effect, as Brand President of IVECO.

The Company thanks Pierre for his leadership of IVECO for the past four and a half years and for his 21 years of service in the Company serving the New Holland Agriculture, IVECO and Heuliez BUS and IVECO brands over this time and wishes him well for the future.

Gerrit Marx, the recently appointed President of CNH Industrial’s Commercial and Speciality Vehicles segment, will assume Pierre Lahutte’s responsibilities.

CNH Industrial N.V. (NYSE: CNHI /MI: CNHI) is a global leader in the capital goods sector with established industrial experience, a wide range of products and a worldwide presence. Each of the individual brands belonging to the Company is a major international force in its specific industrial sector: Case IH, New Holland Agriculture and Steyr for tractors and agricultural machinery; Case and New Holland Construction for earth moving equipment; Iveco for commercial vehicles; Iveco Bus and Heuliez Bus for buses and coaches; Iveco Astra for quarry and construction vehicles; Magirus for firefighting vehicles; Iveco Defence Vehicles for defence and civil protection; and FPT Industrial for engines and transmissions. More information can be found on the corporate website: www.cnhindustrial.com

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Contacts:

Corporate Communications
Email: mediarelations@cnhind.com

Attachment

Radware Report Shows That Respondants Claim Average Cost of Cyberattack Now Exceeds $1 Million

Operational/Productivity Loss (54%) and Negative Customer Experience (43%) are Identified as the Primary Impacts of Cyberattacks

MAHWAH, N.J., Jan. 15, 2019 (GLOBE NEWSWIRE) — Radware® (NASDAQ: RDWR), a leading provider of cybersecurity and application delivery solutions, today announced it has released its 2018-2019 Global Application and Network Security Report, in which survey respondents estimate the average cost of a cyberattack at $1.1M. For those organizations that calculate (versus estimate) the cost of an attack, that number increases to $1.67M. The top impact of cyberattacks, as reported by respondents, is operational/productivity loss (54%), followed by negative customer experience (43%). What’s more, almost half (45%) reported that the goal of the attacks they suffered was service disruption. Another third (35%) said the goal was data theft.

“While threat actors only have to be successful once, organizations must be successful in their attack mitigation 100% of the time,” said Anna Convery-Pelletier, Chief Marketing Officer for Radware. “A cyberattack resulting in service disruption or a breach can have devastating business impacts. In either case, you are left with an erosion of trust between a brand and its constituency.”

While the cost of attack mitigation continues to rise, so does the number of organizations under attack. Most organizations have experienced some type of attack within the course of a year, with only 7% of respondents claiming not to have experienced an attack at all. Twenty one percent reported daily attacks, representing a significant rise from 13% last year. Not only are attacks becoming more frequent, they are also more effective: 78% of respondents hit by a cyberattack experienced service degradation or a complete outage, compared to 68% last year. Even with these numbers, 34% of respondents do not have a cybersecurity emergency response plan in place.

Other key findings of the report include:

  • 43% of respondents reported negative customer experiences and reputation loss following a successful attack.
  • Data leakage and information loss remain the biggest concern to more than one-third (35%) of businesses, followed by service outages.
  • Hackers increased their usage of emerging attack vectors to bring down networks and data centers: Respondents reporting HTTPS Floods grew from 28% to 34%, reports of DNS grew from 33% to 38%, reports of burst attacks grew from 42% to 49%, and reports of bot attacks grew from 69% to 76%.
  • Application-layer attacks cause considerable damage. Two-thirds of respondents experienced application-layer DoS attacks and 34% foresee application vulnerabilities being a major concern in the coming year. More than half (56%) reported making changes and updates to their public-facing applications monthly, while the rest made updates more frequently, driving the need for automated security.
  • 86% percent of surveyed businesses indicated they explored machine-learning (ML) and artificial intelligence (AI) solutions. Almost half (48%) point at quicker response times and better security as primary drivers to explore ML-based solutions.

Radware’s Global Application and Network Security Report, now in its eighth year, is a cross-industry report compiled by Radware’s Emergency Response Team (ERT), leveraging vendor-neutral survey data from 790 IT executives spanning several industries around the globe, Radware’s hands-on experience handling today’s leading threats, as well as third-party service provider commentary. The complete Global Application & Network Security Report 2018-2019, which details 2018’s major attack trends and provides predictions and recommendations from Radware’s ERT for how organizations can best prepare for mitigating cyber threats in 2019, can be downloaded at https://www.radware.com/ert-report-2018/

THIS PRESS RELEASE AND THE REPORT ARE PROVIDED FOR INFORMATIONAL PURPOSES ONLY. THESE MATERIALS ARE NOT INTENDED TO BE AN INDICATOR OF RADWARE’S BUSINESS PERFORMANCE OR OPERATING RESULTS FOR ANY PRIOR, CURRENT OR FUTURE PERIOD.

About Radware

Radware® (NASDAQ: RDWR), is a global leader of cyber security and application delivery solutions for physical, cloud, and software defined data centers. Its award-winning solutions portfolio secures the digital experience by providing infrastructure, application, and corporate IT protection and availability services to enterprises globally. Radware’s solutions empower more than 12,500 enterprise and carrier customers worldwide to adapt to market challenges quickly, maintain business continuity and achieve maximum productivity while keeping costs down. For more information, please visit www.radware.com.

Radware encourages you to join our community and follow us on: FacebookLinkedInRadware BlogTwitterYouTubeRadware Connect app for iPhone® and our security center DDoSWarriors.com that provides a comprehensive analysis on DDoS attack tools, trends and threats.

©2019 Radware Ltd. All rights reserved. The Radware products and solutions mentioned in this press release are protected by trademarks, patents and pending patent applications of Radware in the U.S. and other countries. For more details please see: https://www.radware.com/LegalNotice/. All other trademarks and names are property of their respective owners.

Safe Harbor Statement
This press release may contain statements concerning Radware’s future prospects that are “forward-looking statements” under the Private Securities Litigation Reform Act of 1995. Statements preceded by, followed by, or that otherwise include the words “believes”, “expects”, “anticipates”, “intends”, “estimates”, “plans”, and similar expressions or future or conditional verbs such as “will”, “should”, “would”, “may” and “could” are generally forward-looking in nature and not historical facts. For example, when we say that “the cost of attack mitigation continues to rise, so does the number of organizations under attack”, this is a forward looking statement. Because such statements deal with future events, they are subject to various risks and uncertainties and actual results, expressed or implied by such forward-looking statements, could differ materially from Radware’s current forecasts and estimates. Factors that could cause or contribute to such differences include, but are not limited to: the impact of global economic conditions and volatility of the market for our products; changes in the competitive landscape; inability to realize our investment objectives; timely availability and customer acceptance of our new and existing products; risks and uncertainties relating to acquisitions; the impact of economic and political uncertainties and weaknesses in various regions of the world, including the commencement or escalation of hostilities or acts of terrorism; Competition in the market for Application Delivery and Network Security solutions and our industry in general is intense; and other factors and risks on which we may have little or no control. This list is intended to identify only certain of the principal factors that could cause actual results to differ. For a more detailed description of the risks and uncertainties affecting Radware, reference is made to Radware’s Annual Report on Form 20-F, which is on file with the Securities and Exchange Commission (SEC) and the other risk factors discussed from time to time by Radware in reports filed with, or furnished to, the SEC. Forward-looking statements speak only as of the date on which they are made and, except as required by applicable law, Radware undertakes no commitment to revise or update any forward-looking statement in order to reflect events or circumstances after the date any such statement is made. Radware’s public filings are available from the SEC’s website at www.sec.gov or may be obtained on Radware’s website at www.radware.com.

Media Contacts:
Deborah Szajngarten
Radware
201-785-3206
deborah.szajngarten@radware.com

Investor Relations:
Anat Earon-Heilborn
+972 723917548
ir@radware.com

January’s Tax Collecting Is Targeted To Touch Rp 2.3 Trillion

Jakarta Taxation and Retribution Agency (BPRD) is targeting to collect Rp 2.3 trillion tax revenue in January.

From total 13 types of tax revenue, Jakarta BPRD Acting (Plt) Head, Faisal Syafruddin stated, his side has a target that needs to be achieved per month thus tax could be realized optimally by the end of the year.

“We are targeting to collect Rp 2.3 trillion this January. Tax realization will be calculated by the end of this month,” he mentioned, Monday (1/14).

He ensures to intensify tax collecting thus this year’s target of Rp 44.108 trillion can be achieved.

“We will optimize tax collecting thus we can reach 100 percent of our target for this year,” he asserted.

Source: Berita Jakarta