Daily Archives: July 23, 2018

Neuralstem Announces Presentation of Preclinical Data Demonstrating Neurogenic Compound NSI-189 Improves Cognition and Anxiety in a Mouse Model of Alzheimer’s Disease

  • Study evaluated the effect of oral treatment with NSI-189 in well-established 5xFAD mouse model for Alzheimer’s disease (AD)
  • Treatment with NSI-189 restored memory retention and learning abilities in AD mice, and reduced anxiety in control and AD mice

GERMANTOWN, Md., July 23, 2018 (GLOBE NEWSWIRE) — Neuralstem, Inc. (Nasdaq:CUR), a biopharmaceutical company developing novel treatments for nervous system diseases, today announced the presentation of data at the Alzheimer’s Association International Conference in Chicago, Illinois, demonstrating that oral administration of NSI-189 in a mouse model of Alzheimer’s Disease leads to a significant amelioration and/or improvement in cognition measures and anxiety. Results are being presented in a poster titled ‘Effect of Neurogenic Compound NSI-189 on Indices of Cognition and Anxiety in a Mouse Model (5XFAD) of Alzheimer’s Disease.’

The study was carried out by Dr. Corinne Jolivalt’s laboratory at the University of California, San Diego, and involved the oral administration of NSI-189 to mice harboring gene changes that recreate symptoms of familial Alzheimer’s disease. Animals were treated starting at 15 weeks of age, when memory defects are first beginning to appear. Key findings include:

  • Treatment with NSI-189 significantly improved learning ability as well as retention as measured by a simple task (Barnes maze), and improved performance on a test of short term memory (Novel Object Recognition)
  • Treatment with NSI-189 improved motor learning of AD mice as measured by performance on a Rotarod test
  • NSI-189 treatment decreased anxiety levels in both AD mice and control mice as measured by an open field test

“Data from this preclinical study suggest that NSI-189 may be able to mitigate or reverse the cognitive impact of Alzheimer’s disease,” said Corinne Jolivalt, PhD, associate professor in the Department of Pathology at UC San Diego School of Medicine. “We look forward to continuing this line of inquiry to further evaluate the potential of NSI-189 in the treatment of this devastating disease.”

About Alzheimer’s disease

Alzheimer’s disease is a chronic, neurodegenerative disorder that causes progressive dementia as well as a decline in other aspects of cognition which can affect a person’s ability to interact socially or function at work. There are currently an estimated 50 million people living with dementia around the world, with numbers expected to triple by 2050.  The total estimated annual social and economic cost of dementia is $818 billion USD worldwide and is expected to reach a trillion in the coming years.

About Neuralstem

Neuralstem is a clinical-stage biopharmaceutical company developing novel treatments for nervous system diseases of high unmet medical need. The Company has two lead development candidates:

  • NSI-189, is a small molecule in clinical development for major depressive disorder and in preclinical development for Angelman syndrome, irradiation-induced cognitive impairment, Type 1 and Type 2 diabetes, and stroke.
  • NSI-566 is a stem cell therapy being tested for treatment of paralysis in stroke, Amyotrophic Lateral Sclerosis (ALS) and chronic spinal cord injury (cSCI).

Neuralstem’s diversified portfolio of product candidates is based on its proprietary neural stem cell technology.

Cautionary Statement Regarding Forward Looking Information

This news release contains “forward-looking statements” made pursuant to the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements relate to future, not past, events and may often be identified by words such as “expect,” “anticipate,” “intend,” “plan,” “believe,” “seek” or “will.” Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Specific risks and uncertainties that could cause our actual results to differ materially from those expressed in our forward-looking statements include risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem’s periodic reports, including the Annual Report on Form 10-K for the year ended December 31, 2017 filed with the Securities and Exchange Commission (SEC), and in other reports filed with the SEC. We do not assume any obligation to update any forward-looking statements.

Contact:

Kimberly Minarovich
Argot Partners (Investor Relations)
212-600-1902
neuralstem@argotpartners.com

Creative Technology Opens CT Japan Office in Tokyo

TOKYO, July 22, 2018 (GLOBE NEWSWIRE) — Creative Technology (CT), a worldwide outsourced technical production partner for corporate live events and exhibition producers and an NEP Live Events Company, announced the opening of operations in Tokyo to meet the growing demand for its services in Japan. CT Japan will provide extensive audio, lighting, LED and projection, media management, and technical solutions to clients in the corporate live events and exhibition marketplace.

CT also announced that Kazuyuki Kai, who joined the company in June, will head business development and operations for CT Japan and serve as the key contact for major events and cross-divisional initiatives. He brings more than 10 years’ experience to his role, most recently as a senior sales and project manager at an international AV production house in Tokyo.

“We are excited to formally open an office in Tokyo with Kai spearheading our efforts for this very important market,” said Chris Burke, Managing Director of CT Asia Pacific. “His expertise in managing high-profile events for corporations, as well as government entities, is enabling us to build a strong team locally while delivering superior service and innovative solutions for our clients.”

Kazuyuki Kai and the CT Japan team can be reached via email at kkai@ctasiapacific.com or by calling +81 70 3194 7620. To learn more about CT Japan’s solutions, visit www.ct-group.com.

About Creative Technology
Creative Technology (CT), an NEP Live Events Company, is one of the world’s leading suppliers of specialist Audio Visual equipment to the corporate, exhibitions, sport and entertainment industries. Founded over 32 years ago as a video specialist, our portfolio has diversified to include audio-visual production facilities, lighting, digital and associated products and services. Our bespoke events staging services bring together advice, support and equipment of the highest quality, providing everything from large screen displays to content delivery systems for events of every size and type.

Our ability to combine the most innovative, experienced and specialist minds in our industry with world class technology and the highest levels of engineering and operational support is what makes CT unique. With local operations in 19 offices on three continents, we have worked in locations and venues across the globe to provide superior service to our clients.

Learn more by visiting us at www.ct-group.com.

About NEP
For over 30 years, NEP has been a worldwide outsourced technical production partner supporting premier content producers of live sports, entertainment, music and corporate events. Our services include remote production, studio production, audio visual solutions, host broadcast support, premium playout, post production and innovative software-based media management solutions. NEP’s 3,000+ employees are driven by a passion for superior service and a focus on technical innovation. Together, we have supported productions in over 85 countries on all seven continents.

NEP is headquartered in the United States and has offices in 24 countries.

Chris Burke, Managing Director
CT Asia Pacific
+65 6295 0562
cburke@ctasiapacific.com

Regional development is constitutional mandate, president says

Jakarta (ANTARA News) – President Joko Widodo said the development of infrastructure projects implemented in a number of isolated region and villages constitutes the mandate of the constitution.

“We know that the name of justice and equity is the mandate of the constitution that we must implement them,” President Jokowi said in his speech during the Commemoration of Birthday Party of the National Awakening Party at Grand Sahid Jaya Hotel, here on Sunday night.

According to the President, the government is still developing remote areas to drive the economy in the regions.

In addition, the Head of State reminded the energy of the Indonesian nation should not be exhausted just to deal with differences in political choices.

Other countries have focused on the era of the 4th industrial revolution by developing transportation technology to telecommunication media, Jokowi explained.

Currently, the President added, global competition in the economy is happening.

“Right now we are confronting global economic pressures that we are inevitably facing together, because our great assets are united in the face of global challenges that are not getting easier, but more difficult,” Jokowi said.

The government is building a number of infrastructure in some areas including Trans Papua road, Trans Sumatra toll road, Trans Java toll road, as well as seaports and airports.

In addition, the government also provides village funds to the village governments to build facilities and infrastructure in rural areas such as irrigation, village roads and toilet facilities.

In 2015 the government disbursed Rp20.76 trillion in the form of village funds, then Rp46.9 trillion in 2016 and Rp60 trillion in 2017.

Source: ANTARA News

Regional development is constitutional mandate, president says

Jakarta (ANTARA News) – President Joko Widodo said the development of infrastructure projects implemented in a number of isolated region and villages constitutes the mandate of the constitution.

“We know that the name of justice and equity is the mandate of the constitution that we must implement them,” President Jokowi said in his speech during the Commemoration of Birthday Party of the National Awakening Party at Grand Sahid Jaya Hotel, here on Sunday night.

According to the President, the government is still developing remote areas to drive the economy in the regions.

In addition, the Head of State reminded the energy of the Indonesian nation should not be exhausted just to deal with differences in political choices.

Other countries have focused on the era of the 4th industrial revolution by developing transportation technology to telecommunication media, Jokowi explained.

Currently, the President added, global competition in the economy is happening.

“Right now we are confronting global economic pressures that we are inevitably facing together, because our great assets are united in the face of global challenges that are not getting easier, but more difficult,” Jokowi said.

The government is building a number of infrastructure in some areas including Trans Papua road, Trans Sumatra toll road, Trans Java toll road, as well as seaports and airports.

In addition, the government also provides village funds to the village governments to build facilities and infrastructure in rural areas such as irrigation, village roads and toilet facilities.

In 2015 the government disbursed Rp20.76 trillion in the form of village funds, then Rp46.9 trillion in 2016 and Rp60 trillion in 2017.

Source: ANTARA News